Effect of treatment duration on the associations between three modern antidiabetic drugs and survival outcomes of lung cancer in China
Longer treatment durations of GLP-1RA, SGLT-2I, and DPP-4I reduced the risks of disease progression and mortality in lung cancer patients with type 2 diabetes. Among these drug classes, GLP-1RA showed consistent benefits while DPP-4I and SGLT-2I had non-linear associations, with shorter treatment durations being linked to higher risk.
Authors
- Ye Huang (ORCID: https://orcid.org/0000-0002-8691-4924)
- Xiaonan H. Wang (ORCID: https://orcid.org/0000-0002-1023-8499)
- Zijia Chen (ORCID: https://orcid.org/0009-0009-6303-5095)
- Yang Lu (ORCID: https://orcid.org/0000-0002-0352-0832)
- Yupeng Di (ORCID: https://orcid.org/0000-0002-1635-8918)
- C. Z. Lei
- Yan Li
- Zhongtao Zhang
Institutions
- Hebei Medical University (CN)
- Guangzhou University of Chinese Medicine (CN)
- Hengshui University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fourth Hospital of Hebei Medical University (CN)
- Xiyuan Hospital (CN)
- Air Force General Hospital PLA (CN)
- Guang’anmen Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fmolb.2025.1701515
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00