Associations between glutamate and cerebral blood flow in treatment-resistant schizophrenia during clozapine treatment
These results indicate that there is a direct relationship between changes in glutamate activity and CBF in the striatum following clozapine treatment. Future research could investigate whether glutamate-CBF relationships exist in other stages of psychosis or schizophrenia and during treatment with other antipsychotic medications. Associations with clinical outcomes could be explored in larger samples.
Authors
- Oliver Howes (ORCID: https://orcid.org/0000-0002-2928-1972)
- Kyra-Verena Sendt (ORCID: https://orcid.org/0000-0002-7191-0541)
- Amy Gillespie (ORCID: https://orcid.org/0000-0003-4640-699X)
- Junyu Sun (ORCID: https://orcid.org/0000-0001-5532-3593)
- Grant McQueen (ORCID: https://orcid.org/0000-0001-8259-5439)
- Alice Egerton (ORCID: https://orcid.org/0000-0003-2939-064X)
- David J. Lythgoe (ORCID: https://orcid.org/0000-0002-5078-9025)
- James Hunter MacCabe (ORCID: https://orcid.org/0000-0002-6754-1018)
- Philip K. McGuire (ORCID: https://orcid.org/0000-0003-4381-0532)
- Gareth John Barker
- Owen O’Daly
- Fernando Zelaya
- John Lally
Institutions
- University College Dublin (IE)
- Wellcome Centre for Human Neuroimaging (GB)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Warneford Hospital (GB)
- University of Oxford (GB)
- St. Vincent's University Hospital (IE)
Publication Details
- Journal
- Journal of Psychopharmacology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1177/02698811251409141
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00