Immune Profiling Identifies High-Risk Neutrophil-Rich Subtype in Checkpoint Inhibitor Nephritis
Our findings identify distinct ICI-AIN subtypes, with a neutrophil-rich cluster linked to complement activation and poor prognosis, offering insights into refining diagnosis and treatment strategies.
Authors
- Hamza Sakhi (ORCID: https://orcid.org/0000-0003-4977-2661)
- Stéphanie Chhun (ORCID: https://orcid.org/0000-0001-6278-4128)
- Idris Boudhabhay (ORCID: https://orcid.org/0000-0002-8045-1658)
- Anne Grünenwald
- Pierre Isnard (ORCID: https://orcid.org/0000-0002-1880-7596)
- Hélène Lazareth (ORCID: https://orcid.org/0000-0002-1500-3736)
- Nicolas Veyrenche (ORCID: https://orcid.org/0000-0001-5948-5039)
- Marie-Sophie Meuleman
- Elsa Ferrière
- Julie Oniszczuk
- Béatrice Regnault (ORCID: https://orcid.org/0000-0002-3914-1914)
- Florence Runyo
- Céline Mayinga
- Meher Burki
- Francesca Lucibello (ORCID: https://orcid.org/0000-0003-2806-1908)
- A. Karras
- Lubka Roumenina
- Nicolas Girard
- Elizabeth Fabre
- Jean-Paul Duong Van Huyen
- Alaeddine Redissi
- Marie Agnes Dragon-Durey
- Philippe Pérot
- Emma Fleury
- Olivier Aubert
- Jacques Fourgeaud
- Houcine Hamidi
- Marion Rabant
- Camille Cohen
- Anne Jamet
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Hôpital Necker-Enfants Malades (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Institut Necker Enfants Malades (FR)
- Centre Hospitalier Universitaire de La Réunion (RE)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- Centre Hospitalier Intercommunal de Poissy (FR)
- Institut du Thorax (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Hôpital Foch (FR)
- Institut Curie (FR)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.ekir.2025.103766
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 24.20