Widening access to penicillin allergy assessment in the United Kingdom—a proposed implementation plan for the National Health Service (NHS)

Globally, there is increasing evidence that incorrect penicillin allergy labels negatively affect patient outcomes, antibiotic prescribing and antimicrobial resistance, leading to growing concern about this patient safety issue and how to resolve it. While many millions of patients worldwide have incorrect penicillin allergy labels, there are too few specialist allergists and a lack of 'point-of-care' tests to address this problem. Numerous research studies now provide evidence of the feasibility and importance of widening access to penicillin allergy assessment. Researchers from two UK-based studies (SPACE and ALABAMA), in collaboration with key stakeholders including patient representatives, gave their views to shape a high-level implementation plan to facilitate widening access to penicillin allergy assessment in the UK. This Viewpoint describes the basis of the implementation plan and summarizes the key actions required for successful delivery. While the plan is intended for the UK, we hope to promote international shared learning and collaboration to address this global problem informed by the UK context.

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Publication Details

Journal
JAC-Antimicrobial Resistance
Published
2025-12-02
DOI
https://doi.org/10.1093/jacamr/dlaf240
Primary Topic
Drug-Induced Adverse Reactions
Type
article
Field-Weighted Citation Impact
0.00
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article

Widening access to penicillin allergy assessment in the United Kingdom—a proposed implementation plan for the National Health Service (NHS)

Jonathan Sandoe, Philip Howard, Louise Savic, Neil Powell et al.
JAC-Antimicrobial Resistance
Drug-Induced Adverse Reactions
article

Widening access to penicillin allergy assessment in the United Kingdom—a proposed implementation plan for the National Health Service (NHS)

Jonathan Sandoe, Philip Howard, Louise Savic, Neil Powell, Iestyn Williams, Claire Bethune, Siraj Misbah, Mamidipudi Thirumala Krishna, Jenny Boards, Caity Roleston, Sinisa Savic, Colin Stewart Brown, C Jamieson, Pavitt Sue, Joanne Fielding, Andrew C Moss, Catherine E Porter, Ian Clarke, Sarah Tonkin-Crine
article en

Abstract

Globally, there is increasing evidence that incorrect penicillin allergy labels negatively affect patient outcomes, antibiotic prescribing and antimicrobial resistance, leading to growing concern about this patient safety issue and how to resolve it. While many millions of patients worldwide have incorrect penicillin allergy labels, there are too few specialist allergists and a lack of 'point-of-care' tests to address this problem. Numerous research studies now provide evidence of the feasibility and importance of widening access to penicillin allergy assessment. Researchers from two UK-based studies (SPACE and ALABAMA), in collaboration with key stakeholders including patient representatives, gave their views to shape a high-level implementation plan to facilitate widening access to penicillin allergy assessment in the UK. This Viewpoint describes the basis of the implementation plan and summarizes the key actions required for successful delivery. While the plan is intended for the UK, we hope to promote international shared learning and collaboration to address this global problem informed by the UK context.

JAC-Antimicrobial ResistanceVol. 8(1)
University of Leeds (GB), University Hospitals Birmingham NHS Foundation Trust (GB), Department of Health and Social Care (GB), Leeds Teaching Hospitals NHS Trust (GB), Royal Cornwall Hospital Trust (GB), Leeds Community Healthcare NHS Trust (GB), National Institute for Health and Care Research (GB), University of Oxford (GB), Liga Contra el Cancer (PE), The Edgbaston Hospital (GB), Institut thématique Immunologie, inflammation, infectiologie et microbiologie (FR), NIHR Leeds Musculoskeletal Biomedical Research Unit (GB), East and North Hertfordshire NHS Trust (GB), Digital Catapult (GB), Oxford University Hospitals NHS Trust (GB), Leeds Dental Hospital (GB), University Hospitals Plymouth NHS Trust (GB), NHS England, University of Birmingham (GB)
Partnerships for the goals
Openalex Percentile: Top 28%
Drug-Induced Adverse Reactions
DOIOpen Access PDFOpenAlex
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