Prognostic value of tumour-associated neutrophils in different polarization status releasing neutrophil extracellular traps in the immunotherapy of advanced non-small cell lung cancer
Tumour-associated N2 neutrophils in NSCLC tissues are the primary cells releasing NETs, and tumour-associated N2 neutrophils with high NETs expression are associated with an immunosuppressive tumour microenvironment, which will impact the efficacy of first-line immunotherapy in NSCLC patients.
Authors
- Dengying Chen
- Weiwei Hong
- Y Y Li (ORCID: https://orcid.org/0000-0002-9693-1883)
- Chunli Luo (ORCID: https://orcid.org/0000-0002-1092-494X)
- Lin Chen (ORCID: https://orcid.org/0000-0001-7905-2505)
- Xinxin Yao (ORCID: https://orcid.org/0000-0002-2309-9678)
- Bo Yu (ORCID: https://orcid.org/0000-0002-7257-2855)
- Zhaoqing Li (ORCID: https://orcid.org/0009-0002-5504-7802)
- Bingbiao Zhou
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Xiaoying Qian
- Chengsi Shu
- Yan Yin
- Chen Fang
- Xin Ye
- Xiangzhi Chai
- Guizhen Qin
Institutions
- Nanchang University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fonc.2025.1705716
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nanchang University
- Education Department of Jiangxi Province
- Health Commission of Jiangxi Province