Pulmonary nocardiosis masquerading as refractory haemoptysis in a bronchiectasis patient: the critical role of multidisciplinary management
An immunocompetent male in his 30s with a history of bronchiectasis presented with recurrent haemoptysis (5-10 mL every 2 months) over 4 years. High-resolution CT revealed cystic bronchiectasis and ground-glass opacities. Bronchoscopy identified active bleeding from a ruptured bronchial artery, which was successfully managed with emergent embolisation. Bronchoalveolar lavage demonstrated weakly acid-fast branching filaments, later confirmed as <i>Nocardia asteroides</i> by matrix-assisted laser desorption-ionisation time of flight mass spectrometry. The patient responded well to trimethoprim-sulfamethoxazole and remained stable at follow-up.This case highlights three key points: (1) pulmonary nocardiosis should be considered in chronic haemoptysis, especially in patients with structural lung disease, even if immunocompetent; (2) rapid microbiological diagnosis is critical, particularly when acid-fast staining yields atypical results; and (3) bronchial artery embolisation can be lifesaving in cases of nocardial vasculitis with active bleeding. The report underscores the importance of multidisciplinary management in such complex presentations.
Authors
- Babaji Ghewade (ORCID: https://orcid.org/0000-0003-1553-7268)
- Poonam Patil
- Aarnav Mehta
- Amisha Harish Soni
Institutions
- Datta Meghe Institute of Higher Education and Research (IN)
Publication Details
- Journal
- BMJ Case Reports
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1136/bcr-2025-268534
- Primary Topic
- Actinomycetales infections and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00