Epstein Barr viral shedding dynamics in saliva during acute SARS-CoV-2 infection
This cohort study provides evidence that SARS-CoV-2 infection is associated with prolonged salivary EBV shedding, that concurrent high levels of EBV and SARS-CoV-2 in saliva are correlated, but these salivary EBV shedding dynamics do not drive systemic EBV antibody responses. Further research with larger cohorts and mechanistic assays would be helpful to elucidate the biological pathway triggering systemic EBV antibody responses.
Authors
- Timothy J. Henrich (ORCID: https://orcid.org/0000-0002-6684-0622)
- Badri Viswanathan (ORCID: https://orcid.org/0009-0001-4779-5037)
- Isidro X. Perez‐Añorve
- Sarah A. Goldberg (ORCID: https://orcid.org/0000-0002-8642-1468)
- Miguel Garcia-Knight (ORCID: https://orcid.org/0000-0001-9556-3719)
- Michael J. Peluso (ORCID: https://orcid.org/0000-0003-0585-6230)
- Jessica Y. Chen (ORCID: https://orcid.org/0000-0002-4833-6756)
- Khamal Anglin (ORCID: https://orcid.org/0000-0002-1801-5345)
- Michel Tassetto (ORCID: https://orcid.org/0000-0001-5666-8796)
- Scott Lu
- Jeffrey N. Martin
- Steven G. Deeks
- Amethyst Zhang
Institutions
- San Francisco General Hospital (US)
- San Francisco VA Medical Center (US)
- University of California, San Francisco (US)
- Universidad Autónoma Metropolitana (MX)
- Wellcome Sanger Institute (GB)
- San Francisco Foundation (US)
- University of California San Francisco Medical Center (US)
- Global Brain Health Institute (US)
- University of San Francisco (US)
- Universidad Nacional Autónoma de México (MX)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-05
- DOI
- https://doi.org/10.64898/2025.12.31.25343091
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention
- National Institute of Allergy and Infectious Diseases