Crotonylation-related gene GCDH promotes osteoarthritis pathogenesis through flavin adenine dinucleotide signaling: mechanism exploration and experimental validation
The crotonylation gene <i>GCDH</i> was identified as a potential risk factor for OA pathogenesis, thus providing a novel molecular target and interventions for the development of targeted OA therapeutic strategies.
Authors
- Zijian Guo (ORCID: https://orcid.org/0000-0003-3435-2365)
- LuYi Zhang
- Yunfeng Di
- Feida Wang
- Yingda Qin (ORCID: https://orcid.org/0009-0005-3960-8915)
- Chuan Xiang
- Jingkai Di
Institutions
- Shanxi Medical University (CN)
- First Hospital of Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fnut.2025.1646005
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00