Multi-target mechanisms of glabrone in ulcerative colitis: Synergistic restoration of mucosal barrier and inhibition of inflammation through SRC/HSP90 Co-modulation
Glabrone ameliorates UC through coordinated modulation of SRC/HSP90, which synergistically promotes mucosal barrier restoration and suppresses inflammatory responses. These results provide theoretical basis for developing Glabrone as a candidate multi-target therapeutic agent for UC.
Authors
- Yuxuan Xu (ORCID: https://orcid.org/0000-0002-7961-5096)
- Ming Luo (ORCID: https://orcid.org/0000-0002-3070-0927)
- Yamei Li
- Zhu Hong-xia
- Yiquan Peng (ORCID: https://orcid.org/0009-0009-4688-4714)
- Junya Wen
- Qiang Liu
- Yufan Wu
- Yuge Wu
- Zhuxian Wang
Institutions
- Southern Medical University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.biopha.2025.118951
- Citations
- 1
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 30.63