TO EXPLORE THE POTENTIAL OF VIRECHANOTTARA ASHWAGANDHA GHANA VATI AND SHLESHMAKALNALA RASA WITH AGNIMANTHADI KASHAYA ANUPANA IN ATOPIC TRIAD ON SPIROMETRIC VALUES AND IGE LEVELS

Atopic triad, encompassing asthma, allergic rhinitis, and atopic dermatitis, correlates in Ayurveda with Śvāsa, Pratiśyaya, and Vicarcikā. These disorders share an underlying Th2-dominant immune response characterized by elevated IgE, eosinophilia, and inflammatory mediators such as histamine and cytokines (IL-4, IL-5, IL-13), leading to chronic inflammation and hypersensitivity. An open-labelled randomized controlled trial was conducted on 60 patients fulfilling inclusion criteria, divided equally into two groups. Group A received Virechana followed by Shleshmakalanala Rasa and Ashwagandha Ghana Vaṭi with Agnimanthādi Kaśāya as Anupāna, while Group B received standard allopathic treatment. Group A showed highly significant improvement in subjective symptoms of Śvāsa, Pratiśyaya, and Vicarcikā, along with objective parameters—AEC, FEV₁, FVC, and FEV₁/FVC—and a significant reduction in IgE levels. Group B exhibited improvement in spirometric values and AEC but no significant change in IgE. Findings suggest that the Ayurvedic protocol offers superior outcomes in both clinical and immunological parameters compared to conventional management. Virechana followed by Shleshmakalanala Rasa and Ashwagandha Ghana Vaṭi with Agnimanthādi Kaśāya enhances respiratory efficiency, reduces allergic response, and provides an effective integrative approach for managing the Atopic Triad.