RIPK3-driven phosphorylation of MFN2 orchestrates endoplasmic reticulum-mitochondria interaction and cardiomyocyte stress responses
Our findings reveal that RIPK3 can mediate MFN2 phosphorylation to promote ER-mitochondria interaction and mitochondrial Ca<sup>2+</sup> overload, leading to the induction of cardiac necroptosis.
Authors
- Peiyan Wang (ORCID: https://orcid.org/0000-0003-1368-3632)
- Tao Xu (ORCID: https://orcid.org/0000-0003-0433-2611)
- Xiang Ao (ORCID: https://orcid.org/0000-0002-6474-2025)
- P. Wang
- Qing Li (ORCID: https://orcid.org/0000-0003-3087-4692)
- Lin Ye (ORCID: https://orcid.org/0000-0002-0303-2409)
- Wei Ding (ORCID: https://orcid.org/0000-0003-3564-970X)
- Yanru Wang (ORCID: https://orcid.org/0000-0001-8272-2450)
- Yihan Song
- Jianxun Wang
Institutions
- Qingdao University (CN)
- Qingdao Agricultural University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Redox Biology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.redox.2026.104006
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00