PET/MR imaging of LC‐NE function for interrogation of health disparity in preclinical AD
NET availability is higher in young AA and declines faster in old AA. These two competing factors result in a reduced group difference seen in old cohort. We demonstrate that LC-NE function is sensitive to both age and stress effects and confirm that [<sup>11</sup>C]MRB-PET is a promising strategy for early detection of underlying mechanisms for the health disparity in preclinical AD.
Authors
- Henry Rusinek (ORCID: https://orcid.org/0000-0001-6035-6314)
- Matthew Arthur
- Sachita Gupta
- Oliver Cesar
- Andrew R. Kelleher (ORCID: https://orcid.org/0000-0002-9175-2712)
- Yu‐Shin Ding
- jingyun chen
- Jennifer Bernal
- Anmol S Bhatia
- Ujjval Chopra
- Ding's Lab
- Artem Mikheev
Institutions
- Columbia University Irving Medical Center (US)
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_105090
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00