AMP deaminase-2- and adenosine deaminase-mediated disposal of β-cell intracellular adenosine protects against multiple low-dose streptozotocin-induced type 1 diabetes
β-cells differ from α-cells in terms of the metabolism and disposal of intracellular adenosine, which makes β-cells more vulnerable to ATP-depleting stress, and therefore also more prone to being attacked by the immune system in T1D.
Authors
- Anongnad Ngamjariyawat
- Averina Octaxena Aslani (ORCID: https://orcid.org/0000-0002-5325-5061)
- Mudhir Sabir Shekha (ORCID: https://orcid.org/0000-0002-9552-838X)
- Martin Blixt
- Zhengkang Luo (ORCID: https://orcid.org/0000-0002-0051-3047)
- Ronja Andersson
- Kailash Singh (ORCID: https://orcid.org/0000-0002-0966-7771)
- Nils Welsh
- S. Sandler
- Kina Adjieva (ORCID: https://orcid.org/0009-0005-3729-3593)
- Tongjian Zhao
Institutions
- Thammasat University (TH)
- Uppsala University (SE)
- Salahaddin University-Erbil (IQ)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.biopha.2025.118914
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00