No cytotoxic silver(I) complexes as antibacterial and antibiofilm agents with BSA and DNA binding properties
The complexes <b>2a-d</b> exhibited a significant inhibitory effect on diverse bacterial biofilms, with percentages ranging from 73.6% to 80.3% for <i>S.aureus</i>, 69.5% to 85.9% for <i>E.faecalis</i>, 76.9% to 88.6% for <i>E.coli</i>, 75.9% to 84.6% for <i>A.baumannii</i> and 70.1% to 82.3% for <i>C.albicans</i>. The most significant activities were observed with complex <b>2b</b> at 8.5 µM. It was observed that silver(I) complexes exhibited more effective binding to DNA (4.92 × 10<sup>3</sup> for 2a), while NHC precursors displayed a higher binding affinity for BSA (5.52 × 10<sup>4</sup> with 1-isopropyl-3-(3-methylbenzyl)-5,6-dimethylbenzimidazole chloride). While the precursors of ligands exhibited significant toxicity at their highest MIC concentrations, the complexes demonstrated minimal toxicity.
Authors
- Uğur Tutar (ORCID: https://orcid.org/0000-0002-8058-0994)
- Mehmet Ataş (ORCID: https://orcid.org/0000-0002-9425-0080)
- Elvan Üstün (ORCID: https://orcid.org/0000-0002-0587-7261)
- Neslihan Şahin (ORCID: https://orcid.org/0000-0003-1498-4170)
- Cem Çeli̇k (ORCID: https://orcid.org/0000-0002-7141-5874)
- Z. Akin Polat
- D Semeril
Institutions
- Sivas Cumhuriyet Üniversitesi (TR)
- Malatya Turgut Özal Üniversitesi (TR)
- Ordu University (TR)
- Turgut Özal University (TR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Future Medicinal Chemistry
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1080/17568919.2025.2610632
- Citations
- 1
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 24.20