Deciphering the immunomodulatory mechanisms of Periplaneta americana L. extract CII-3: insight from integrated metabolomics and network pharmacology
The proposed approach provides a valuable evidence for demonstrating the material basis of CII-3. The results obtained in the present study elucidated that the potential immunomodulatory activity of CII-3 might be closely associated with these crucial targets, which can modulate the levels of major metabolites through multiple metabolic pathways, thus ameliorating immunosuppression.
Authors
- Yán Wāng (ORCID: https://orcid.org/0000-0002-2940-3300)
- Xi Liu
- Yingxiang Wu
- Yang Jin
- Yilin Wang
- Jiali Zhu
- Tianqian Li
- Zhiyan Lu
Institutions
- Dali Traditional Chinese Medicine Hospital (CN)
- Dali University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fcell.2025.1718560
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Yunnan Province
- Yunnan Provincial Science and Technology Department
- Dali University