Safety Assessment of Repeated Oral Administration of Tolfenamic Acid in Japanese Quails: Haematological, Biochemical and Histopathological Evaluations

These findings indicate that tolfenamic acid administration does not adversely affect haematological or biochemical parameters. Although biochemical parameters remained normal, histopathological changes such as tissue damage may indicate early or subclinical injury that could impair organ function over time. These microscopic alterations might lead to long-term health issues in quails, even without biochemical abnormalities. Therefore, cautious dosing and regular tissue monitoring are important when using tolfenamic acid.