Catalyst free multicomponent reactions of 4-aminocumarin for the green synthesis of novel pyrrolonaphthyridine

This study successfully synthesized fused chromeno[1,8]-naphthyridines, which belong to a novel class of fused heterocyclic compounds, employing a multicomponent reaction with excellent efficiency. The process utilized 4-aminocumarin, 2-arylidenemalononitrile, and activated acetylenic chemicals in an aqueous solution at room temperature, with the presence of Cu@Fe3O4/SiO2@MWCNTs serving as a reusable catalyst. This study investigates the antioxidant effects of fused chromeno[1,8]-naphthyridines, as well as other studies conducted in this study. The synthesis of fused chromeno[1,8]-naphthyridines exhibited various beneficial characteristics, such as fast reactions, high yields of the end product, and easy isolation of the catalyst and product from the reaction mixture.