Prognostic relevance of specific TIL (CD4+, CD8+, and FOXP3 + T-cell infiltrates) in triple-negative breast cancer: short- and long-term outcomes
These findings suggest that high levels of CD4 + T cells and CD8 + T cells are positive predictors of immediate, long-term prognosis and clinical prognosis in patients with TNBC. This study enhances the understanding on the immunological interests in specific subtypes of TIL and identifies potential biomarkers that could drive advancements in precision medicine for breast cancer management.
Authors
- Olga Caramelo (ORCID: https://orcid.org/0000-0003-0825-6732)
- T. Almeida-Santos
- Ana Fidalgo (ORCID: https://orcid.org/0000-0002-1530-5742)
- Augusta Cipriano
- Vânia Almeida
Institutions
- Escola Superior de Tecnologia da Saúde de Coimbra (PT)
- Mahle (Portugal) (PT)
- University of Coimbra (PT)
Publication Details
- Journal
- Breast Cancer
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1007/s12282-025-01819-y
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia