Prediction of prognosis and immunotherapy response of tryptophan metabolism genes in acute myeloid leukemia
Our integrative analysis identified key tryptophan-metabolism-related genes in AML and developed a six-gene TRPRS capable of accurately distinguishing survival risk. This model not only provides mechanistic insights into AML progression but also offers a framework for individualized risk stratification and therapeutic guidance.
Authors
- Panpan Feng
- P. Q. Li
- Na Wang (ORCID: https://orcid.org/0000-0001-6050-3150)
- Zhihui Qi
- Xianghua Wang
- Xiaosheng Fang
- Meirui Zhang
- Xinran Qi
- Tantan Zhong
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fphar.2025.1714246
- Primary Topic
- Acute Myeloid Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province