Nitrogen-rich hyper-cross-linked polymers for rapid and selective bilirubin removal in hemoperfusion
Liver failure causes the accumulation of endogenous toxins in the blood; their efficient removal is crucial to support hepatic recovery. Hemoperfusion is an effective detoxification modality but remains limited by the performance of adsorbents. Herein, we report a benzotriazole-functionalized hyper-cross-linked polymer (HCP) with excellent performance as a hemoperfusion adsorbent for the removal of bilirubin. The synthesized HCP exhibits outstanding performance for bilirubin capture, delivering a maximum adsorption capacity of 877 mg g<sup>-1</sup> and an equilibrium capacity of 195 mg g<sup>-1</sup>. This work expands the application of HCPs and provides a viable construction strategy for the development of hemoperfusion adsorbents.
Authors
- Chang Gao (ORCID: https://orcid.org/0000-0001-7825-0024)
- Yanling Cai (ORCID: https://orcid.org/0009-0006-5758-3130)
- Hongxiang Yin
- Wei Yan
- Irshad Hussain
- Yueyuan Xiao
- Bien Tan
- Jiarui Hu
Institutions
- Lahore University of Management Sciences (PK)
- Ministry of Education (RO)
- Shenzhen Technology University (CN)
- Ministry of Education (MV)
- Hubei University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1039/d5cc06484h
- Primary Topic
- Organ Transplantation Techniques and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00