Continuous versus Intermittent Midazolam Sedation in Balloon-Assisted Enteroscopy: A Multicenter Randomized Trial

Continuous infusion of midazolam did not demonstrate superiority over intermittent bolus administration with regard to the proportion of time under conscious sedation. However, continuous infusion suppressed body movements during BAE without increasing adverse events; thus, it could be one of the feasible sedation options for BAE in clinical practice.

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Publication Details

Journal
Digestion
Published
2026-01-06
DOI
https://doi.org/10.1159/000550292
Primary Topic
Anesthesia and Sedative Agents
Type
article
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article

Continuous versus Intermittent Midazolam Sedation in Balloon-Assisted Enteroscopy: A Multicenter Randomized Trial

T Wakatsuki, Yuko Sakakibara, Takuya Yamada, K. Mabe et al.
Digestion
Anesthesia and Sedative Agents
article

Continuous versus Intermittent Midazolam Sedation in Balloon-Assisted Enteroscopy: A Multicenter Randomized Trial

T Wakatsuki, Yuko Sakakibara, Takuya Yamada, K. Mabe, Akiko Kada, Shinji Katsushima, Tomohiko Mannami, T Kanda, Toshio Uraoka, Naoki Esaka, Toshio Kuwai, Mototsugu Kato, Naohiko Harada, Kimitoshi Kubo, Akio Ishihara, Yuzuru Tamaru, Takashi Kagaya, Mizuki Kuramochi, Hiroyuki Fujii, Masaaki Shimada, Shohei Hamada, Akiko M. Saito, Yoshihiro Sasaki, Noriko Watanabe, Tatsuya Toyokawa, on behalf of the NHO Network Gastrointestinal Study Group
article en

Abstract

Continuous infusion of midazolam did not demonstrate superiority over intermittent bolus administration with regard to the proportion of time under conscious sedation. However, continuous infusion suppressed body movements during BAE without increasing adverse events; thus, it could be one of the feasible sedation options for BAE in clinical practice.

Digestion
Gunma University (JP), Kyoto Medical Center (JP), National Kyushu Medical Center (JP), Fukuyama University (JP), Osaka National Hospital (JP), Kanazawa Medical Center (JP), Tokyo Medical Center (JP), Fukuyama City Hospital (JP), Higashi Osaka City General Hospital (JP), Fukuyama Cardiovascular Hospital (JP), Fukuoka Higashi Medical Center (JP), Saitama Municipal Hospital (JP), Mie Chuo Medical Center (JP), Okayama Medical Center (JP), Nagoya Medical Center (JP), National Disaster Medical Center (JP), Hakodate National Hospital (JP), Kure Medical Center (JP)
Good health and well-being
Openalex Percentile: Top 94%
Anesthesia and Sedative Agents
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