Melatonin and agomelatine alleviate ivermectin-induced mouse spermatogonia apoptosis via suppression of oxidative stress and calcium overload
Melatonin and agomelatine protect the male reproductive system from drug-induced toxicity by restoring redox homeostasis and mitochondrial function. These findings provide mechanistic insight into melatonin-based therapeutic strategies and the development of fertility preserving agents targeting mitochondria-mediated cellular injury.
Authors
- Seung Hee Shin (ORCID: https://orcid.org/0009-0008-3566-3185)
- Daniel Chavez Varias (ORCID: https://orcid.org/0009-0006-3636-7797)
- Sung-Hwan Moon
- Buom-Yong Ryu
- Kennlee Orola
- Soon-Jung Park
Institutions
- Biosolution (South Korea) (KR)
- Chung-Ang University (KR)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fcell.2025.1713124
- Primary Topic
- Parasitic Diseases Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00