Single-Cell Resolution Drug Effects of Renin-Angiotensin-Aldosterone Blockade in ZSF1 Rat Diabetic Kidney Disease
We reported cathepsin D as an important regulator of enalapril effects, involving cross-talk between the distal nephron and triggering receptor expressed on myeloid cells 2+ residential macrophages. We also demonstrated that enalapril-associated gene signatures allow stratification of human kidney samples by disease-relevant outcome measures.
Authors
- Ziyuan Ma (ORCID: https://orcid.org/0000-0002-1512-8993)
- Manuel Grundmann (ORCID: https://orcid.org/0000-0002-4473-7851)
- Mira Pavkovic (ORCID: https://orcid.org/0000-0001-5112-7851)
- Amin Abedini (ORCID: https://orcid.org/0000-0002-8875-0070)
- Katalin Suszták (ORCID: https://orcid.org/0000-0002-1005-3726)
- Jianfu Zhou
- Yanjuan Hou
- Tejaswini Yadav
- Michael S. Balzer
Institutions
- Penn Center for AIDS Research (US)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Bayer (Germany) (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Pennsylvania (US)
Publication Details
- Journal
- Journal of the American Society of Nephrology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1681/asn.0000000995
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00