Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations

Genetic susceptibility to severe COVID-19 and PASC in Indian populations appears to be linked to dysregulation of pathways central to cardiac and neurological function. These findings, derived from an exploratory PASC GWAS, provide preliminary insights into the molecular mechanisms that may underlie the post-viral sequelae. These emphasize the need for population-wide genomic studies to validate the candidate associations, better understand PASC risk, and facilitate the development of precision diagnostics and therapeutics.

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Journal
Frontiers in Genetics
Published
2026-01-05
DOI
https://doi.org/10.3389/fgene.2025.1696764
Primary Topic
Genetics and Neurodevelopmental Disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations

Narendra Kumar, Ranajit Das, Hrushikesh Udupa, Siddappa Nagadenahalli Byrareddy et al.
Frontiers in Genetics
Genetics and Neurodevelopmental Disorders
article

Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations

Narendra Kumar, Ranajit Das, Hrushikesh Udupa, Siddappa Nagadenahalli Byrareddy, Arpan Acharya, P Sunil, Priyanka Upadhyai, Pooja Umesh Shenoy, A. I. Ananthakrishnan, Urvinder Kaur Sardarni
article en

Abstract

Genetic susceptibility to severe COVID-19 and PASC in Indian populations appears to be linked to dysregulation of pathways central to cardiac and neurological function. These findings, derived from an exploratory PASC GWAS, provide preliminary insights into the molecular mechanisms that may underlie the post-viral sequelae. These emphasize the need for population-wide genomic studies to validate the candidate associations, better understand PASC risk, and facilitate the development of precision diagnostics and therapeutics.

Frontiers in GeneticsVol. 16
Nebraska Medical Center (US), Yenepoya University (IN), Manipal Academy of Higher Education (IN)
University of Nebraska Medical Center, Yenepoya Research Centre, College of Medicine, University of Nebraska Medical Center
Openalex Percentile: Top 96%
Genetics and Neurodevelopmental Disorders
DOIOpen Access PDFOpenAlex
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Genomic and ancestral variations linked to the development of post-acute sequelae of SARS-CoV-2 infection in Indian populations — Narendra Kumar, Ranajit Das, et al. · Frontiers in Genetics (2026) | TGRS Research Map | TGRS