Maternal undernutrition inhibits fetal rumen development: novel miRNA-736-mediated dual targeting of E2F2 and MYBL2 in sheep
In summary, maternal undernutrition disrupted male fetal rumen metabolism and elevated novel miR-736, which targeted and downregulated E2F2 and MYBL2 to inhibit cell cycle progression and promote apoptosis, finally inhibited male fetal rumen development. This study provides new insights into the epigenetic mechanisms underlying maternal undernutrition-induced male fetal rumen developmental deficits.
Authors
- Jianbo Cheng (ORCID: https://orcid.org/0000-0002-6192-9038)
- Caiyun Fan
- Yamei Gu
- Baoyuan Li
- Mianqun Zhang (ORCID: https://orcid.org/0000-0001-5110-174X)
- Huizhen Lu (ORCID: https://orcid.org/0009-0004-6143-7502)
- Yun Xu
- Shengyong Mao
- Yanfeng Xue
- Wen Zhu
- Peng Jiao
Institutions
- Nanjing Agricultural University (CN)
- Anhui Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s40104-025-01321-7
- Primary Topic
- Reproductive Physiology in Livestock
- Type
- article
- Field-Weighted Citation Impact
- 0.00