Intravenous leiomyomatosis involving the inferior vena cava and right atrium with postoperative pulmonary embolism: a case report

Intravenous leiomyomatosis (IVL) is a rare subtype of benign smooth muscle tumor that can exhibit malignant-like biological behavior. Originating in the uterus, IVL grows in mass-like formations within small veins and can extend into the inferior vena cava (IVC), right atrium, and pulmonary arteries. Due to the potential for life-threatening consequences when IVL invades the heart and pulmonary arteries, early diagnosis and radical resection through a multidisciplinary approach are crucial. This report presents a case of uterine intravenous leiomyomatosis involving the IVC and right atrium, complicated by massive pulmonary embolism after surgery, and includes a literature review to discuss the clinical implications.

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Publication Details

Journal
Frontiers in Surgery
Published
2026-01-06
DOI
https://doi.org/10.3389/fsurg.2025.1692371
Primary Topic
Uterine Myomas and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Intravenous leiomyomatosis involving the inferior vena cava and right atrium with postoperative pulmonary embolism: a case report

Xin Xia, W. Li, Qin Wang, Jiaqing Liu et al.
Frontiers in Surgery
Uterine Myomas and Treatments
article

Intravenous leiomyomatosis involving the inferior vena cava and right atrium with postoperative pulmonary embolism: a case report

Xin Xia, W. Li, Qin Wang, Jiaqing Liu, Wangwei Zhang, Aobo Zhuang, Yukai Chen
article en

Abstract

Intravenous leiomyomatosis (IVL) is a rare subtype of benign smooth muscle tumor that can exhibit malignant-like biological behavior. Originating in the uterus, IVL grows in mass-like formations within small veins and can extend into the inferior vena cava (IVC), right atrium, and pulmonary arteries. Due to the potential for life-threatening consequences when IVL invades the heart and pulmonary arteries, early diagnosis and radical resection through a multidisciplinary approach are crucial. This report presents a case of uterine intravenous leiomyomatosis involving the IVC and right atrium, complicated by massive pulmonary embolism after surgery, and includes a literature review to discuss the clinical implications.

Frontiers in SurgeryVol. 12
Xiamen University (CN), First Affiliated Hospital of Xiamen University (CN), Zhongshan Hospital of Xiamen University (CN), China Medical University (CN)
Xiamen Municipal Bureau of Science and Technology, National Natural Science Foundation of China, Fujian Provincial Department of Science and Technology, Xiamen University
Good health and well-being
Openalex Percentile: Top 97%
Uterine Myomas and Treatments
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Intravenous leiomyomatosis involving the inferior vena cava and right atrium with postoperative pulmonary embolism: a case report — Xin Xia, W. Li, et al. · Frontiers in Surgery (2026) | TGRS Research Map | TGRS