Neonatal neurocritical care considerations for prenatally identified neurological disorders

With increased access to advanced prenatal neuroimaging and genetic testing, neurological disorders such as brain malformations, brain injuries, and genetic disorders, are increasingly being diagnosed during pregnancy. In this review, we address neonatal neurocritical care considerations for the population with prenatally identified neurological disorders. We identify antenatal considerations, including planning location of delivery, as well as postnatal considerations, including clinical phenotyping, neuromonitoring, neuroimaging, and genetic testing. The importance of interdisciplinary collaboration between obstetrics, maternal-fetal medicine, neonatology, pediatric neurology, neuroradiology, genetics, palliative care, early intervention and habilitative services is emphasized. We outline high-priority research gaps, and highlight the need for large, multicenter studies that capture diverse geographies, populations, care practices and settings longitudinally. IMPACT: Fetal neurology is a rapidly evolving field owing to the increased prenatal diagnosis of neurological disorders; however, the natural history of many fetal neurological disorders is not well known. We identify interdisciplinary neonatal neurocritical care considerations for newborns with prenatally diagnosed neurological disorders, such as neuroimaging, neuromonitoring, and family support. We outline high-priority research gaps in fetal neurology relevant to neurocritical care, including the need to prioritize large-scale longitudinal studies on the etiologies, short- and long-term outcomes of fetal neurologic disorders across diverse geographies and populations to improve counseling and care.

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Publication Details

Journal
Pediatric Research
Published
2026-01-07
DOI
https://doi.org/10.1038/s41390-025-04691-w
Primary Topic
Fetal and Pediatric Neurological Disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Neonatal neurocritical care considerations for prenatally identified neurological disorders

Monica E. Lemmon, Tomo Tarui, Mark S. Scher, Lara M. Leijser et al.
Pediatric Research
Fetal and Pediatric Neurological Disorders
article

Neonatal neurocritical care considerations for prenatally identified neurological disorders

Monica E. Lemmon, Tomo Tarui, Mark S. Scher, Lara M. Leijser, Andrea Pardo, SONIKA AGARWAL, Anthony R Hart, Courtney J. Wusthoff, Charu Venkatesan, Kaashif A. Ahmad, James P. Boardman, Brigitte Vollmer, Thiviya Selvanathan, Eleanor J. Molloy, Latha Srinivasan, Doctor Dawn Gano, Vann Chau, Emily M. Herzberg, Sarah B. Mulkey, Barbara Scelsa, Gabrielle deVeber, Eric S. Peeples, Firdose Nakwa, Hany Aly
article en

Abstract

With increased access to advanced prenatal neuroimaging and genetic testing, neurological disorders such as brain malformations, brain injuries, and genetic disorders, are increasingly being diagnosed during pregnancy. In this review, we address neonatal neurocritical care considerations for the population with prenatally identified neurological disorders. We identify antenatal considerations, including planning location of delivery, as well as postnatal considerations, including clinical phenotyping, neuromonitoring, neuroimaging, and genetic testing. The importance of interdisciplinary collaboration between obstetrics, maternal-fetal medicine, neonatology, pediatric neurology, neuroradiology, genetics, palliative care, early intervention and habilitative services is emphasized. We outline high-priority research gaps, and highlight the need for large, multicenter studies that capture diverse geographies, populations, care practices and settings longitudinally. IMPACT: Fetal neurology is a rapidly evolving field owing to the increased prenatal diagnosis of neurological disorders; however, the natural history of many fetal neurological disorders is not well known. We identify interdisciplinary neonatal neurocritical care considerations for newborns with prenatally diagnosed neurological disorders, such as neuroimaging, neuromonitoring, and family support. We outline high-priority research gaps in fetal neurology relevant to neurocritical care, including the need to prioritize large-scale longitudinal studies on the etiologies, short- and long-term outcomes of fetal neurologic disorders across diverse geographies and populations to improve counseling and care.

Pediatric Research
Northwestern University (US), Cincinnati Children's Hospital Medical Center (US), Nebraska Medical Center (US), Cleveland Clinic (US), Children's National (US), University of Calgary (CA), Duke University (US), University of California, San Francisco (US), University of Toronto (CA), University of the Witwatersrand (ZA), George Washington University (US), Trinity College Dublin (IE), National Foundation for Cancer Research (US), Royal London Hospital (GB), Hospital for Sick Children (CA), University Hospital Southampton NHS Foundation Trust (GB), Children's Health Ireland at Crumlin (IE), Coombe Women & Infants University Hospital (IE), Mednax (United States) (US), King's College Hospital NHS Foundation Trust (GB), Hasbro Children's Hospital (US), MRC Centre for Reproductive Health (GB), Southampton Children's Hospital (GB), Ospedale dei Bambini Vittore Buzzi (IT), SickKids Foundation (CA), Institute for Clinical Evaluative Sciences (CA), Children's Hospital & Medical Center (US), BC Children's Hospital (CA), St. James's Hospital (IE), University of Southampton (GB), University College London (GB), Case Western Reserve University (US), University of Cincinnati (US), University of Pennsylvania (US), University of California, Davis (US), University of Edinburgh (GB)
BC Children's Hospital
Openalex Percentile: Top 96%
Fetal and Pediatric Neurological Disorders
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