Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study
This study identifies ITGB7 as a novel pathogenic gene for CHD and reveals its multiomics mechanisms in promoting CHD development through DNA methylation regulation, immune response activation, and metabolic pathway disruption. The findings provide valuable theoretical insights and potential biomarkers for the pathogenesis and targeted intervention of CHD.
Authors
- Junchi Guo
- Meijuan Lu (ORCID: https://orcid.org/0000-0003-3576-0643)
- Peihan Lu
- Fang Huang
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cardiovascular Therapeutics
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1155/cdr/4885476
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00