Distinct Roles of <scp>SLC26A3</scp> and <scp>CFTR</scp> in Surface <scp>pH</scp> Regulation and Bicarbonate Secretion in Human Intestinal Epithelium
SLC26A3 and CFTR perform distinct yet complementary functions. SLC26A3 dominates surface pH regulation and maintains bicarbonate efflux independently of CFTR, while CFTR drives agonist-stimulated fluid secretion. SLC26A3's ability to restore pH homeostasis and normalize mucin intracellular distribution in CF organoids demonstrates its critical importance for maintaining colonic mucosal health.
Authors
- Ursula Elisabeth Seidler (ORCID: https://orcid.org/0000-0002-9600-2769)
- Azam Salari (ORCID: https://orcid.org/0009-0001-4366-8436)
- Mahdi Amiri
Institutions
- Medizinische Hochschule Hannover (DE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1111/apha.70157
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Medizinischen Hochschule Hannover