Mitochondrial DNA released from pyroptotic synovial macrophages via DDIT3-mediated mitophagy aggravates osteoarthritis progression
This study highlights the pivotal role of mtDNA released from pyroptotic synovial macrophages through DDIT3-mediated mitophagy in OA. Targeting inhibition of macrophage pyroptosis by folic acid-modified PLGA nanoparticles might serve as a potential therapeutic target for alleviating cartilage degeneration in OA.
Authors
- Yan Wang
- Chang Yang
- Jiawei Wang
- Qiongdong Xu
- Wei Dong
- Jin Ke
- Wenqian Yu
Institutions
- Wuhan University (CN)
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2026-01-01
- DOI
- https://doi.org/10.1016/j.jot.2025.101036
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00