GP6 polymorphisms and venous thromboembolism: a Chinese case-control study with cross-population assessment

Our findings demonstrate that rs1613662 is associated with a modest but statistically significant increase in VTE susceptibility on average, with heterogeneous effect sizes across different populations. The observed ethnic heterogeneity suggests the necessity of additional investigation into population-specific genetic architectures. Integrated polygenic risk scores could be used to optimize risk stratification and develop preventive strategies against VTE.