Placental Insulin-like Growth Factor 1 Deficiency Drives Autism-Relevant Behavioral Changes with Sex-Specific Vulnerabilities
The provision of <i>Igf1</i> specifically from placenta is critical for offspring forebrain development. This temporary early deficit has persistent sex-specific neurobehavioral effects. These outcomes have relevance for autism risk and highlight mechanisms that could facilitate intervention development for adverse outcomes after early loss of placental hormone support in perinatal adversity.
Authors
- Regan Fair (ORCID: https://orcid.org/0009-0007-6538-2096)
- Hanna Elizabeth Stevens (ORCID: https://orcid.org/0000-0002-3906-0786)
- Robert A. Taylor
- Amrita Gajmer
- Faith Martha Fairbairn
- Annemarie J Carver
- Benjamin W.Q. Hing
Institutions
- University of Iowa (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-06
- DOI
- https://doi.org/10.64898/2026.01.06.697024
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Graduate College, University of Iowa
- National Institute of Mental Health
- National Institute of General Medical Sciences