Macrophage-myofibroblast transition as a novel therapeutic target in shoulder stiffness: multi-omics study and experimental validation
In this study, we proved that MMT was involved in SS progression, and identified POSTN as the key regulator of MMT. POSTN knockdown effectively suppressed MMT, alleviated fibrosis, and restored ROM <i>in vivo</i>. This research elucidated a novel mechanism in SS pathogenesis and developed POSTN as a promising therapeutic target for SS.
Authors
- Weihan Yu
- Yuqi LI
- Hanyi Wang (ORCID: https://orcid.org/0000-0002-5542-165X)
- Beijie Qi (ORCID: https://orcid.org/0000-0002-4041-0050)
- Chengqing Yi (ORCID: https://orcid.org/0000-0003-4159-9673)
- Shuang Deng
Institutions
- Shanghai Jiao Tong University (CN)
- Fudan University (CN)
- Pudong Medical Center (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fcell.2025.1727624
- Primary Topic
- Shoulder Injury and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00