PEAK1 promotes prostate cancer progression and docetaxel resistance by mediating the polarization of tumor-associated macrophages
PEAK1 plays an oncogenic role in prostate cancer by promoting cell metastasis, reducing docetaxel and enzalutamide sensitivity, and mediating "M2" polarization of macrophages by activating the HIF-1α/STAT3/NF-κB pathway.
Authors
- Jianxin Ni
- Zhengqi Shi
- Boxin Guo
- Xuelian Li
- Ruixiao Li
- Yongpan An
- Yongfei Duan
Institutions
- Shaanxi Provincial People's Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1186/s40001-025-03568-2
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 36.44