Prolonged alpha-blockade and doxazosin are associated with hypertensive crisis in pheochromocytoma surgery

Selective α-blockade with doxazosin resulted in longer hypertensive crises, increased intraoperative vasopressor requirements, and prolonged hospitalization. Prolonged α-blockade (>30 days) was associated with more frequent and prolonged hypertensive crises and a higher risk of postoperative vasopressor use.

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Publication Details

Journal
Frontiers in Endocrinology
Published
2026-01-07
DOI
https://doi.org/10.3389/fendo.2025.1682912
Primary Topic
Adrenal and Paraganglionic Tumors
Type
article
Field-Weighted Citation Impact
0.00
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article

Prolonged alpha-blockade and doxazosin are associated with hypertensive crisis in pheochromocytoma surgery

Karolina Zawadzka, Alicja Hubalewska‐Dydejczyk, Michał Pędziwiatr, Magdalena Pisarska
Frontiers in Endocrinology
Adrenal and Paraganglionic Tumors
article

Prolonged alpha-blockade and doxazosin are associated with hypertensive crisis in pheochromocytoma surgery

Karolina Zawadzka, Alicja Hubalewska‐Dydejczyk, Michał Pędziwiatr, Magdalena Pisarska
article en

Abstract

Selective α-blockade with doxazosin resulted in longer hypertensive crises, increased intraoperative vasopressor requirements, and prolonged hospitalization. Prolonged α-blockade (>30 days) was associated with more frequent and prolonged hypertensive crises and a higher risk of postoperative vasopressor use.

Frontiers in EndocrinologyVol. 16
Jagiellonian University (PL)
Good health and well-being
Openalex Percentile: Top 97%
Adrenal and Paraganglionic Tumors
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