Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity
These findings suggest that MLCK1-dependent tight junction regulation is essential for ICIs colitis, positioning barrier restoration as a potential therapeutic strategy.
Authors
- J R Turner
- Chonggui Jiang (ORCID: https://orcid.org/0000-0003-4746-9597)
- Yunsheng Dong
- Wentao Xu (ORCID: https://orcid.org/0000-0003-3490-2769)
- Xianda Wang
- Junhao Zhao (ORCID: https://orcid.org/0000-0001-9896-5959)
- Nina Zhu (ORCID: https://orcid.org/0000-0001-6822-2708)
- Li Zuo
- Wenli Pei (ORCID: https://orcid.org/0000-0003-2525-152X)
- Feng Cao (ORCID: https://orcid.org/0000-0003-1604-1723)
- Huaqing Zhu
- Suthat Liangpunsakul (ORCID: https://orcid.org/0000-0002-6504-8123)
- H Weng
- Lei Xiong
- Zihan Wang (ORCID: https://orcid.org/0000-0001-7475-9501)
- Shanshan Wu (ORCID: https://orcid.org/0000-0001-9791-8093)
- Heng Zhang (ORCID: https://orcid.org/0000-0002-0103-2173)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Yang Han (ORCID: https://orcid.org/0000-0002-0034-5848)
- Ji Wang (ORCID: https://orcid.org/0000-0002-7771-5819)
- Honghai Xu (ORCID: https://orcid.org/0000-0002-3710-8694)
- Sainan Tang
- Jiayi Song (ORCID: https://orcid.org/0009-0008-2741-5915)
- Baoming Wu
- Rumeng Zhu
- Bei Tan
- Chenchen An
- Abduxukur Rahman
- Qiao Mei
- Hanqi Xia
- Bin Bao
- Lanlan Hou
- Jianshang Huang
- Wei-Ting Kuo
- Qiansheng Huang
- Wei Han
Institutions
- Wannan Medical College (CN)
- Fujian University of Traditional Chinese Medicine (CN)
- Boston Children's Hospital (US)
- Harvard University (US)
- National Taiwan University (TW)
- Anhui Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Heidelberg University (DE)
- Peking Union Medical College Hospital (CN)
- University Hospital Heidelberg (DE)
- Wuhu No 1 People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- University Medical Centre Mannheim (DE)
- Ministry of Education (KN)
- First Affiliated Hospital of Wannan Medical College (CN)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Gut
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1136/gutjnl-2025-337780
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 24.20