Extracellular CIRP augments inflammation in acute kidney injury via NKG2D-positive macrophages
In conclusion, eCIRP induces NKG2D<sup>+</sup> macrophages and MULT-1<sup>+</sup> RTECs, and their interaction further increases the inflammatory response. Targeting the NKG2D/MULT-1 may reduce RIR-induced inflammation and thus attenuate AKI.
Authors
- Hui Jin (ORCID: https://orcid.org/0000-0002-6621-9529)
- Max Brenner (ORCID: https://orcid.org/0000-0002-8010-148X)
- Fangming Zhang
- Ping Wang
- Chuyi Tan
Institutions
- Feinstein Institute for Medical Research (US)
- Hofstra University (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3389/fimmu.2025.1703126
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health