Nanos downregulates maternal <scp>mRNAs</scp> in germline during <i>Drosophila</i> early embryogenesis
Our results show that Nanos downregulates maternal mRNA expression in PGCs before ZGA in Drosophila. As Nanos in C. elegans PGCs has also been reported to promote maternal-to-zygotic transition (MZT) via maternal mRNA downregulation during a transcriptionally silent state, our findings highlight the importance of investigating the function of Nanos for understanding the MZT in PGCs across various animal species.
Authors
- Yasuhiro Kozono
- Makoto Hayashi (ORCID: https://orcid.org/0000-0002-3170-6255)
- Satoru Kobayashi (ORCID: https://orcid.org/0000-0003-1127-5328)
- Miho Asaoka
Institutions
- University of Tsukuba (JP)
- Tsukuba University of Technology (JP)
- Tokyo University of Marine Science and Technology (JP)
Publication Details
- Journal
- Developmental Dynamics
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1002/dvdy.70107
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science
- Japan Science and Technology Agency