Integrated sTim-3 and PLA2R-Ab Levels Improve Risk Stratification in PLA2R-Positive Membranous Nephropathy
sTim-3 serves as a complementary biomarker to PLA2R-Ab. Combined detection optimizes PMN risk stratification: PLA2R-Ab >50 RU/mL and sTim-3 >17.63 ng/mL indicates an immune-activated state requiring intensive immunosuppression, preventing overtreatment in PLA2R-Ab-high patients with favorable immune status.
Authors
- Lingli Chen
- H. Gao (ORCID: https://orcid.org/0000-0002-9669-3088)
- Yuan Qin (ORCID: https://orcid.org/0000-0003-0205-5454)
- Xuan Zhou (ORCID: https://orcid.org/0009-0001-3539-9221)
- Biao Huang
- Xuanli Tang
- Xiang Shao
- Shangbin Kao
- Xueqin Zhao
- Yuanyuan Du
- Tianyu Zheng
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Sci-Tech University (CN)
- University of Electronic Science and Technology of China (CN)
- Kowloon Hospital (CN)
- Suzhou Kowloon Hospital (CN)
- Blood Center of Zhejiang Province (CN)
Publication Details
- Journal
- The Nephron journals/Nephron journals
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1159/000550248
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00