Olanzapine affects bone formation via oral Enterococcus through SAA1 gene and extracellular matrix-related pathways
Olanzapine may increase the relative abundance of oral <i>Enterococcus</i>, whose components are plausibly linked to increased expression of <i>SAA1</i> gene and inhibition of bone formation through extracellular matrix-related pathways. These exploratory findings support further exploration of microbiota-based strategies to alleviate skeletal complications and promote oral health. The clinical research presented in this paper has been registered on ClinicalTrials.gov, a platform of the U.S. National Institutes of Health (Registration Number: NCT06123897; URL: https://clinicaltrials.gov/ct2/show/NCT06123897), with the registration date of November 9, 2023.
Authors
- Min-Yuan Wang
- Hui Yuan (ORCID: https://orcid.org/0000-0001-9739-3645)
- Ruixi Liu
- J. W. Li
- Ying Yang (ORCID: https://orcid.org/0000-0002-9799-3293)
- M. Wang
- Senjeet Sreekissoon
- N. Chen
- Yue Guo (ORCID: https://orcid.org/0000-0001-9750-8887)
- Xiao-Lin Su
- Qiong Liu (ORCID: https://orcid.org/0000-0003-1459-448X)
- Qian Zhang (ORCID: https://orcid.org/0000-0001-7746-4231)
- Fengyi Zhang (ORCID: https://orcid.org/0000-0002-2398-8176)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-5768-2802)
- Jin-dong Chen
- He-Qiong Zheng
- Yun-Zhi Feng
- Meng-Mei Zhong
- Li Tan
Institutions
- Central South University (CN)
- National Clinical Research (US)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.3389/fcimb.2025.1673931
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00