Genomic characterization of a virulent multidrug-resistant Salmonella enterica serovar Enteritidis strain isolated from meat rabbits (Oryctolagus cuniculus) in China

The rabbit-derived SE JL228 represents a highly virulent, MDR, and metal-tolerant pathogen. Its ability to invade hBMECs, survive within macrophages, and disseminate systemically underscores its zoonotic potential. Transferable plasmids combining resistance and virulence determinants suggest an increased risk of dissemination within farm environments and beyond. These findings emphasize the urgent need for enhanced surveillance, prudent antimicrobial use, and effective biosecurity measures to mitigate the emergence and dissemination of such hybrid pathogens.