Expression Analysis, Diagnostic and Prognostic Accuracy of microRNAs in Oral Cancer: An Overview With Meta-Analysis

This meta-analysis confirms that dysregulated miRNA expression is significantly associated with both poorer prognosis and moderate-to-high diagnostic accuracy in oral cancer. The consistent directionality of expression changes highlights the biological relevance of specific miRNAs as either oncogenic or tumour-suppressive agents. Despite promising results, substantial variability in noninvasive sample data underscores the need for methodological standardization. Further prospective validation, harmonization of analytic workflows, and robust multicentre studies are essential to support the clinical integration of miRNA biomarkers in oral cancer detection and management.