Radiation-induced acquired expression of PD-L1 and reprogramming of the tumor microenvironment in cervical cancer
RT induces PD-L1 expression and enhances CD8<sup>+</sup> T cell and macrophage infiltration into the TME of patients with cervical cancer. Therefore, it may establish an immunologically favorable context for synergistic action with subsequent immunotherapy.
Authors
- D. Li
- Qiufen Guo
- Wenjie Tang
- Qian Wu (ORCID: https://orcid.org/0000-0002-9990-6181)
- Lu Wang
- Lu Zhang
- Xueliang Zhang
- Peng Xie
- Chunhui Cui
- Xiaolin Li
- Bowen Liu
- Xiaohui Yan
- Jianbo Zhang
Institutions
- Shandong Tumor Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Gynecologic Oncology
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1016/j.ygyno.2025.12.007
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00