Accelerated H2O2 Scavenging on a Nano-MnO2/Ti/PVTF Sandwich

Early oxidative stress caused by titanium implants can impair osseointegration. Manganese dioxide (MnO2) nanozyme coatings have the potential to scavenge H2O2 and simultaneously generate O2 to alleviate hypoxia, but their activity is mostly static, and the ion release is detrimental. A nano-MnO2/Ti/P(VDF-TrFE) sandwich-structured composite was fabricated, and ferroelectric polarization was applied to preset a tunable surface potential. Kelvin probe force microscopy (KPFM) verified a presettable potential within ±500 mV. Steady-state kinetics confirmed an enhancement in overall catalytic efficiency (higher Vmax and lower Km). This translated to a faster initial decomposition rate at a low, physiologically relevant H2O2 concentration (300 μM). Correspondingly, under these oxidative stress conditions, cell survival in the polarized group was higher than that in the unpolarized group, indicating that the enhanced initial rate can have a positive effect in such conditions. Overall, this study demonstrates a proof-of-concept strategy to tune MnO2 nanozyme catalysis using a polarization-preset surface potential, targeting implantation-relevant ROS-rich conditions.