Inhibition of Annexin A2 Facilitates PHB2-Mediated Mitophagy in Cardiomyocytes to Alleviate Cardiac Injury and Remodeling After Infarction
These findings highlight the significance of ANXA2 inhibition as a molecular brake on mitophagy inactivation in cardiomyocytes under MI and uncover an ANXA2-mediated posttranslational mechanism essential for maintaining mitochondrial homeostasis and alleviating heart failure after MI.
Authors
- Qi Wu (ORCID: https://orcid.org/0000-0001-9879-5056)
- X T Li
- K Z Deng
- Qiongxin Wang (ORCID: https://orcid.org/0000-0003-3697-8708)
- Xingguo Liu (ORCID: https://orcid.org/0000-0002-5243-7410)
- Peng Zhang (ORCID: https://orcid.org/0000-0002-6218-1885)
- Di Fan (ORCID: https://orcid.org/0000-0002-8629-1739)
- Zhi-Gang She
- Xiao-Jing Zhang
- Huan-Huan Cai
- Zhendong Xu
- Zhibing Lu
Institutions
- Zunyi Medical University (CN)
- Guangzhou Institutes of Biomedicine and Health (CN)
- Wuhan University (CN)
- Qi2 (US)
- Zhongnan Hospital of Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2026-01-06
- DOI
- https://doi.org/10.1161/circulationaha.125.077780
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.00