Advanced lung cancer inflammation index as a diagnostic indicator of bone turnover in osteoporotic fracture patients: a non-linear analysis
The ALI is positively and non-linearly associated with bone turnover in OPF patients. A low ALI indicates suppressed remodeling, whereas higher ALI values correspond to increased turnover and potentially greater healing capacity. Incorporating systemic health indices such as ALI may represent a diagnostic advance beyond BMD, improving fracture risk stratification and individualized management. Prospective studies should assess its prognostic utility.
Authors
- Jiahao Wang (ORCID: https://orcid.org/0000-0003-2957-764X)
- Ke Lu (ORCID: https://orcid.org/0000-0003-1355-3205)
- Weihong Wang
- Mengcheng Zhu
- Yanming Hao
Institutions
- Jiangsu University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First People's Hospital of Kunshan (CN)
- Traditional Chinese Medicine Hospital of Kunshan (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-07
- DOI
- https://doi.org/10.3389/fendo.2025.1699546
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Jiangsu University
- Government of Jiangsu Province