The Effect of Artemether–Lumefantrine Combined with a Single Dose of Primaquine on Plasmodium falciparum Gametocyte Clearance and Post-Treatment Infectivity to Anopheles arabiensis
High baseline gametocyte density strongly correlated with increased infectivity. Adding SLD-PQ markedly accelerates gametocyte clearance and completely blocks post-treatment transmission. Submicroscopic gametocytemia contributed to residual transmission in the AL-only group. Incorporation of SLD-PQ alongside AL, in line with WHO recommendations, is advised to enhance post-treatment transmission blocking, with continued surveillance.
Authors
- Getnet Atenafu (ORCID: https://orcid.org/0000-0002-0955-6211)
- Awoke Minwuyelet (ORCID: https://orcid.org/0000-0003-2612-9884)
- Giulio Petronio Petronio (ORCID: https://orcid.org/0000-0002-5098-7785)
- Roberto Di Marco (ORCID: https://orcid.org/0000-0001-5075-4597)
- Delenasaw Yewhalaw
Institutions
- University of Molise (IT)
- Jimma University (ET)
- University of Catania (IT)
- Debre Markos University (ET)
Publication Details
- Journal
- Tropical Medicine and Infectious Disease
- Published
- 2026-01-08
- DOI
- https://doi.org/10.3390/tropicalmed11010019
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jimma University
- Addis Ababa University