YiQiFuMai ameliorates hypoperfusion-induced cerebral infarction by targeting the shear stress-PLBD1-glycolysis-angiogenesis axis
YQFM treats hypoperfusion-induced cerebral infarction by modulating endothelial mechanotransduction and glycolysis to enhance collateral vessel formation and cerebral perfusion. This study provides mechanistic insights into YQFM's therapeutic action and highlights the potential of targeting the "shear stress-PLBD1-glycolysis-angiogenesis" axis for developing strategies to improve collateral circulation in hypoperfusion-induced cerebral infarction.
Authors
- Kegang Cao
- P. Zhang
- Yi An (ORCID: https://orcid.org/0000-0001-7553-0071)
- Jiaojiao Liu (ORCID: https://orcid.org/0000-0002-4336-2197)
- Xian Liu (ORCID: https://orcid.org/0009-0009-2147-4073)
- Yiheng Lu
- Qiaosheng Ren
- Guiyu Feng
- Boxuan Du
- Shufang Guo
Institutions
- Beijing University of Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Southeast University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1016/j.phymed.2026.157797
- Primary Topic
- Neurological Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00