FM‐dye inhibition of Piezo2 relieves mechanically evoked pain in mouse models of acute inflammatory and osteoarthritic knee pain
Inhibiting Piezo2 pharmacologically reduced pain-related behaviours in mouse models of inflammatory and OA knee pain, providing evidence of the therapeutic potential of targeting Piezo2.
Authors
- D Q Ren
- Daniel B. Hoffman (ORCID: https://orcid.org/0000-0003-4662-1438)
- Brian T. David
- Rachel E. Miller
- Anne‐Marie Malfait
- Natalie S. Adamczyk
- Shingo Ishihara
- Richard J. Miller
- Alia M. Obeidat
Institutions
- Northwestern University (US)
- Rush University Medical Center (US)
- Chicago Anesthesia Pain Specialists (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2026-01-05
- DOI
- https://doi.org/10.1111/bph.70306
- Primary Topic
- Erythrocyte Function and Pathophysiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00