Extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae from human carriage, the human-polluted environment, and food: Molecular epidemiology of two prospective cohorts in five European metropolitan areas
ESBL-Ec and ESBL-Kp from human carriage showed considerable overlap in ARG content. Furthermore, clonal links were observed frequently between humans and hp-environment, and with lower frequency between humans and food. These findings are consistent with human-to-human transmission as an important driver of ARG spread in humans.
Authors
- Daniel Martak (ORCID: https://orcid.org/0000-0002-7310-9977)
- Jelle Scharringa
- Ad C. Fluit (ORCID: https://orcid.org/0000-0003-3432-0021)
- Julia Guther (ORCID: https://orcid.org/0000-0002-2696-3396)
- Patrick Musicha (ORCID: https://orcid.org/0000-0001-7780-2173)
- Ingo B. Autenrieth (ORCID: https://orcid.org/0000-0003-4573-1336)
- Jan Kluytmans (ORCID: https://orcid.org/0000-0003-2665-6844)
- Ben S. Cooper (ORCID: https://orcid.org/0000-0002-9445-7217)
- Didier Hocquet (ORCID: https://orcid.org/0000-0002-4192-7238)
- Nadine Conzelmann
- Tess D. Verschuuren (ORCID: https://orcid.org/0000-0002-1448-7425)
- María Eugenia Riccio (ORCID: https://orcid.org/0009-0003-5071-2225)
- Siri Göpel
- Peter Silke
- Jesús Rodríguez-Baño
- Evelina Tacconelli
- Elena Salamanca
- Stephan Harbarth
Institutions
- University of Geneva (CH)
- University of Verona (IT)
- Centre National de la Recherche Scientifique (FR)
- Heidelberg University (DE)
- Mahidol University (TH)
- University Hospital Heidelberg (DE)
- University Medical Center Utrecht (NL)
- University of Oxford (GB)
- Centre Hospitalier Universitaire de Besançon (FR)
- Hospital Universitario Virgen Macarena (ES)
- Laboratoire Chrono-Environnement (FR)
- Centro de Investigación Biomédica en Red (ES)
- Université Bourgogne Franche-Comté (FR)
- University Children's Hospital Tübingen (DE)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Instituto de Biomedicina de Sevilla (ES)
- Institute of Medical Microbiology and Hygiene (DE)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-07
- DOI
- https://doi.org/10.1371/journal.pone.0337346
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00